The HISS sender is literally just there to provide a link to the ECU so if you're still using a key that's coded to your bike/ECU then you should be fine.
Having said that, if you're getting a new ignition barrel then you'll likely be having new keys, you'll need a key that's already coded to your ECU to be able to code the new ones to it and it might take a bit of fiddling around. There's should be plenty of articles around on how to code new keys.
Cheers,
Phil